26S Proteasome-Associated UCH Interacting Protein 1

Alternative splicing of the TREX2 gene results in five transcript variants. 26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame, producing a protein structurally unrelated to the other isoforms of Three Prime Repair Exonuclease 2 also encoded by the same gene. This protein interacts with ubiquitin C-terminal hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The physiological role of Ubiquitin C-terminal Hydrolases (UCH) is to hydrolyze C-terminal esters and amides of ubiquitin and to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (From PubMed and NCI) (NCI Thesaurus)

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