| Health / Medical Topics |
60S Ribosomal Protein L7a
Encoded by human RPL7A Gene (L7AE Family), 265-aa 30-kDa Ribosomal Protein L7a is a component of the large 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. (NCI Thesaurus)
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