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7-Hydroxystaurosporine
Definition 1
A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI Thesaurus)
Definition 2
An anticancer drug that belongs to the family of drugs called staurosporine analogues. (NCI Dictionary)
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Indicates that 6th grade is the highest level of educational achievement.
A chromosome band present on 6q
A chromosome band present on 6q
