| Health / Medical Topics |
A-DNA
A-DNA is a shorter and wider helix than B-DNA. Most RNA and RNA-DNA duplex are in this form. While deep, narrow major groove is not easily accessible to proteins but wide, shallow minor groove is accessible to proteins but with lower information content than major groove. A-DNA is the favored conformation at low water concentrations. Base pairs are tilted to helix axis and displaced from axis and sugar pucker is C3'-endo (in RNA 2'-OH inhibits C2'-endo conformation). When examined from the top of the helix, there is a large hole in the middle, the sugar phosphate backbone is at the edge of the helix, and the bases are displaced towards the edge. (NCI Thesaurus)
YOU MAY ALSO LIKE
A regimen consisting of doxorubicin, followed by cyclophosphamide, methotrexate, fluorouracil (CMF), used in the adjuvant setting for the treatment of breast…
An amide analogue of Trichostatin A studied for potential antineoplastic activity. A-65 inhibits zinc-dependent histone deacetylase, inducing terminal cell differentiation and…
The determination of the amount of a proliferation-inducing ligand present in a sample.
A response indicating that something happens or happened a little of the time.
A response indicating that an individual is or has experienced something and that they are a little concerned.
A subjective answer of weak agreement.
