A Kinase Anchor Protein 13

Encoded by human oncogene AKAP13 Gene, 424-amino acid 49 kD A Kinase Anchor Protein 13 is a signal transduction RHO/RAC GEF involved in cytoskeletal organization and cell cycle progression. Alpha helical hydrophilic LBC is conserved among vertebrates and expressed in skeletal muscle, heart, lung, and hematopoietic cells. It contains phosphorylation sites, N-terminal DH and PH domains, and an N-terminal EF-hand motif. LBC binds to PKA RII tethering it near substrates. AKAP13 stimulates RHO/RAC, but not CDC42 or RAS. In ovary, placenta, breast, and testis, 170 kD BRX contains a LBC region preceded by 3 novel regions; C-terminal regions 4 and 5 bind to the ESR1 ligand-binding domain. BRX also binds RXR, PPAR, and THR. Chimeric onco-LBC lacks the C-terminus, which promotes transforming activity. Proto-LBC is membrane bound; onco-LBC is cytosolic. (OMIM, Swiss-Prot, and NCI) (NCI Thesaurus)

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