ABCB1 1 Allele

Human ABCB1-C allele is the wild-type form of the human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene (ABC gene family), located at located at 7q21.1, which encodes multidrug resistance protein 1. Amplification of the ABCB1 gene is a major determinant in the development of multi-drug resistance which decreases the effectiveness of many chemotherapeutic agents used in cancer treatment. (NCI Thesaurus)

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ABCA2 wt Allele

Human ABCA2 wild-type allele is located in the vicinity of 9q34 and is approximately 22 kb in length. This allele, which encodes…

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The ATP-binding cassette (ABC) transporters form one of the largest known protein families and are widespread in bacteria, archaea, and eukaryotes. They…