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ABERRATION
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I. (noun)
Sense 1
Meaning:
An optical phenomenon resulting from the failure of a lens or mirror to produce a good image
Synonyms:
aberration; distortion; optical aberration
Classified under:
Nouns denoting natural phenomena
Hypernyms ("aberration" is a kind of...):
optical phenomenon (a physical phenomenon related to or involving light)
Hyponyms (each of the following is a kind of "aberration"):
chromatic aberration (an optical aberration in which the image has colored fringes)
spherical aberration (an optical aberration resulting in a distorted image)
Derivation:
aberrate (diverge or deviate from the straight path; produce aberration)
Sense 2
Meaning:
A disorder in one's mental state
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("aberration" is a kind of...):
disturbance; folie; mental disorder; mental disturbance; psychological disorder ((psychiatry) a psychological disorder of thought or emotion; a more neutral term than mental illness)
Derivation:
aberrate (diverge from the expected)
Sense 3
Meaning:
A state or condition markedly different from the norm
Synonyms:
aberrance; aberrancy; aberration; deviance
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("aberration" is a kind of...):
abnormalcy; abnormality (an abnormal physical condition resulting from defective genes or developmental deficiencies)
Hyponyms (each of the following is a kind of "aberration"):
chromosomal aberration; chromosomal anomaly; chromosonal disorder; chrosomal abnormality (any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities)
deflection; warp (a twist or aberration; especially a perverse or abnormal way of judging or acting)
Derivation:
aberrate (diverge or deviate from the straight path; produce aberration)
aberrate (diverge from the expected)
Context examples:
Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
(MYC Gene, NCI Thesaurus)
This tumor is part of a spectrum that includes round cell liposarcoma and that is characterized by recurrent cytogenetic aberrations: t(12;16)(q13;p11) and t(12;22)(q13;q12).
(Myxoid Liposarcoma, NCI Thesaurus)
The source of alteration can be environmental, or due to internal aberration such as a mutation.
(Phenocopy Alteration, NCI Thesaurus)
This aberration is associated with infant acute myeloid leukemia.
(MNX1/ETV6 Fusion Gene, NCI Thesaurus)
This gene is involved in transcriptional regulation and aberrations in the gene are associated with acute leukemias due to chromosomal translocations.
(MLLT6 Gene, NCI Thesaurus)
Mutations or aberrations in the gene result in Birt-Hogg-Dube syndrome.
(FLCN wt Allele, NCI Thesaurus)
In a large number of studies, 8-Methoxypsoralen in combination with ultraviolet A radiation induced chromosomal aberrations, sister chromatid exchanges, mutation, DNA damage and DNA cross-links in human cells in vitro.
(Methoxsalen With Ultraviolet A Therapy, NCI Thesaurus)
This chromosomal aberration is associated with acute monoblastic leukemia.
(MLLT10/CLP1 Fusion Gene, NCI Thesaurus)
Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome.
(CLTCL1 wt Allele, NCI Thesaurus)
There is a recurrent cytogenetic aberration: t(12;22)(q13;q12).
(Clear cell sarcoma of soft tissue, NCI Thesaurus)
