| Health / Medical Topics |
ABT-751
Definition 1
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called sulfonamides. (NCI Dictionary)
Definition 2
An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI Thesaurus)
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