Library / English Dictionary

ACETYLATE

Pronunciation (US):

(GB):

 I. (verb) 

Sense 1

Meaning:

Introduce an acetyl group into (a chemical compound)

Synonyms:

acetylate; acetylise; acetylize

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "acetylate" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Domain category:

chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)

Sentence frame:

Somebody ----s something

Derivation:

acetyl (the organic group of acetic acid (CH3CO-))

acetylation (the process of introducing an acetyl group into a compound)

Sense 2

Meaning:

Receive substitution of an acetyl group

Example:

the compounds acetylated

Synonyms:

acetylate; acetylise; acetylize

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "acetylate" is one way to...):

change (undergo a change; become different in essence; losing one's or its original nature)

Domain category:

chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)

Sentence frame:

Something ----s

Derivation:

acetyl (the organic group of acetic acid (CH3CO-))

acetylation (the process of introducing an acetyl group into a compound)

Credits

 Context examples: 

Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis.

(Arginine butyrate, NCI Thesaurus)

This allele, which encodes acylamino-acid-releasing enzyme protein, is involved in the hydrolysis of N-acetylated peptides.

(APEH wt Allele, NCI Thesaurus)

GD2, an O-acetylated disialoganglioside with expression in normal tissues restricted primarily to the cerebellum and peripheral nerves, is commonly expressed at high levels on tumors of neuroectodermal origins such as melanomas and neuroblastomas.

(Anti-GD2 Monoclonal Antibody hu14.18K322A, NCI Thesaurus)

In addition, Acetyl Coenzyme A acts as a biological acetylating agent.

(Acetyl Coenzyme A, NCI Thesaurus)

Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation.

(Aspirin, NCI Thesaurus)

Upon administration, the BET bromodomains 2, 3 and 4 inhibitor OTX015 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides.

(BET Bromodomains 2/3/4 Inhibitor OTX015, NCI Thesaurus)

Upon administration, the BET inhibitor TEN-010 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones.

(BET Inhibitor TEN-010, NCI Thesaurus)

Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides.

(BET Inhibitor GSK525762, NCI Thesaurus)

Upon administration, the BET inhibitor CPI-0610 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides.

(BET Inhibitor CPI-0610, NCI Thesaurus)

Upon cutaneous administration, SHP-141 selectively binds to and inhibits HDAC, resulting in an accumulation of highly acetylated histones in the skin (dermis and epidermis), the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes.

(HDAC Inhibitor SHP-141, NCI Thesaurus)