| Health / Medical Topics |
Acridine
A polycyclic aromatic dye with antineoplastic, antimicrobial and imaging activities. Acridine and its derivatives intercalate within DNA and RNA by forming hydrogen-bonds and stacking between base pairs resulting in DNA crosslinks and strand breaks. In addition, acridine and its derivatives are a potent inhibitor of topoisomerase II enzyme. This results in the inhibition of DNA and RNA synthesis, predominantly occurring during S phase of the cell cycle and ultimately leads to cell death. (NCI Thesaurus)
YOU MAY ALSO LIKE
A unit of area equal to 4046.87261 square meters. The unit is based on the USA survey foot of 1200/3937 meters. …
A unit of area in British Imperial system named also the international acre. It is equal to 4046.8564224 square meters, or 10…
Human ACRBP wild-type allele is located in the vicinity of 12p13.31 and is approximately 9 kb in length. This allele, which encodes…
This gene plays a role in the compartmentalization of acrosomal matrix and is associated with a number of cancers.
A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular…
Reddening of the palmar and plantar regions of the body with occasional involvement of the distal extremities.
