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Acridine carboxamide
Pronunciation
Definition 1
A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor. Also called DACA. (NCI Dictionary)
Definition 2
A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death. (NCI Thesaurus)
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