Acrosin Binding Protein

Definition 1

Encoded by human ACRBP Gene, 540-amino acid 61 kD Acrosin Binding Protein (CT Family) is similar to proacrosin binding protein sp32 precursor found in pig, mouse, and guinea pig. Expressed in normal testis only, but detected in a range of tumor types such as bladder, breast, lung, liver, and colon, this immunogenic protein is located in the sperm acrosome and may package and condense proacrosin in the acrosomal matrix. (from SWISS-PROT, LocusLink, and NCI) (NCI Thesaurus)

Definition 2

This protein is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. (NCI Thesaurus/LocusLink)

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