ACSL6/ETV6 Fusion Gene

A fusion gene that results from a chromosomal translocation t(5;12)(q31;p13) which fuses the 5' portion of the ACSL6 gene and the 3' portion of the ETV6 gene. In a patient with acute myelogenous leukemia with eosinophilia, this rearrangement fused exons 1-9 of the ACSL6 gene to either intron 2 or exon 3 of the ETV6 gene and does not produce a fusion protein. In one patient with refractory anemia with excess blasts with basophilia, this rearrangement fused exon 19 of the ACSL6 gene with a site within exon 1 of the ETV6 gene and could result in the production of a fusion protein. (NCI Thesaurus)

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ACSL6 wt Allele

Human ACSL6 wild-type allele is located in the vicinity of 5q31 and is approximately 205 kb in length. This allele, which encodes…

ACSL6 Gene

This gene is involved in the biosynthesis of lipids.

ACSL3 wt Allele

Human ACSL3 wild-type allele is located within 2q34-q35 and is approximately 84 kb in length. This allele, which encodes long-chain-fatty-acid--CoA ligase 3…

ACSL3 Gene

This gene is involved in lipid biosynthesis.

ACSL1 wt Allele

Human ACSL1 wild-type allele is located within 4q34-q35 and is approximately 70 kb in length. This allele, which encodes long-chain-fatty-acid-CoA ligase 1…

ACSL1 Gene

This gene plays a role in lipid biosynthesis and fatty acid degradation.