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Activator of S Phase Kinase
Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2. (NCI Thesaurus)
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