Adamantinoma of Long Bones

A low grade malignant neoplasm arising from the long bones. The tibia is the most frequently affected bone site. Patients present with swelling which may or may not be associated with pain. Morphologically, it is characterized by a biphasic pattern consisting of an epithelial and an osteofibrous component. The vast majority of cases recur if they are not treated with radical surgery. In a minority of cases the tumor may metastasize to other anatomic sites including lymph nodes, lungs, liver, brain, and skeleton. (NCI Thesaurus)

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ADAM8 wt Allele

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ADAM8 Gene

This gene is involved in the mediation of proteolysis.

ADAM17 wt Allele

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ADAM17 Gene

This gene plays a role in the cleavage of membrane proteins, resulting in the release of their extracellular domains from cells. …

ADAM15 wt Allele

Human ADAM15 wild-type allele is located in the vicinity of 1q21.3 and is approximately 11 kb in length. This allele, which encodes…