| Health / Medical Topics |
Adenine Nucleotide Translocator-2
Encoded by human SLC25A5 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric integral membrane protein Adenine Nucleotide Translocator-2 contains 3 Solcar repeats and catalyzes ADP/ATP exchange of across the inner mitochondrial membrane. ANT2 facilitates ADP/ATP exchange between the cytosol and mitochondria. The mitochondrial permeability transition pore (mtPTP) complex, which includes ANT, mediates sudden increase in inner mitochondrial membrane permeability common in apoptosis. (NCI Thesaurus)
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