Health / Medical Topics |
Adenosine A2A receptor antagonist PBF-509
An orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells. (NCI Dictionary)
YOU MAY ALSO LIKE
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being…
A finding about one or more characteristics of adenosarcoma, following the rules of the TNM AJCC v7 classification system.
A pathologic finding about one or more characteristics of adenosarcoma, following the rules of the TNM AJCC v7 classification system.
A pathologic finding about one or more characteristics of adenosarcoma, following the rules of the TNM AJCC v7 classification system as they…
A pathologic finding about one or more characteristics of adenosarcoma, following the rules of the TNM AJCC v7 classification system as they…
A clinical finding about one or more characteristics of adenosarcoma, following the rules of the TNM AJCC v7 classification system.