Adenosine Receptor

Definition 1

One of the purinergic P1 receptors that prefers adenosine to other endogenous purines. (NCI Thesaurus)

Definition 2

The three conserved (GPCR Family) widely expressed types of Adenosine Receptors (A1, A2, A3) exhibit specific patterns of ligand binding and unique tissue distributions. Each cell-surface integral membrane protein receptor contains a 7 transmembrane domain and interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate or suppress cAMP accumulation through adenylate cyclase activation or inhibition. Regulating diverse physiologic functions (cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation), adenosine receptors modulate the activity of neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress. (NCI Thesaurus)

YOU MAY ALSO LIKE

Adenosine Nucleotide Transporter

The most abundant mitochondrial protein, Adenine Nucleotide Translocator (ANT), is a homodimer of 30-kD subunits embedded asymmetrically in the inner mitochondrial membrane…

Adenosine Diphosphate Measurement

The determination of the amount of adenosine diphosphate present in a sample.

Adenosine Deaminase Inhibitor

Any substance that inhibits adenosine deaminase, an enzyme involved with the degradation of adenine in purine metabolism and that acts as a…

Adenosine Deaminase Deficiency

An autosomal recessive deficiency of the purine salvage enzyme adenosine deaminase which results in Severe Combined Immunodeficiency Disease (SCID). The most…

Adenosine Deaminase

Adenosine deaminase (363 aa, ~41 kDa) is encoded by the human ADA gene. This protein plays a role in purine metabolism. …

Adenosine Cyclic 3',5'-Phosphate

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is…