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Adenosine Receptor A3
Widely expressed by human ADORA3 Gene (GPCR1 Family), 318-aa 36-kDa Adenosine A3 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains and 3 potential N-glycosylation sites that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition. ADORA3 exhibits about 71% homology with A3ar (rat). Released during ischemia, adenosine exerts a potent protective effect through ADORA3 on cardiac ventricular cells. ADORA3 may have a role in reproduction. (NCI Thesaurus)
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