| Health / Medical Topics |
Adenylate Cyclase
Adenylyl cyclases are membrane-associated enzymes of the lyase class that are expressed in most human tissues. These enzymes catalyze the formation of cyclic AMP and pyrophosphate from ATP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium. Adenylyl cyclase is encoded by the ADCY9 gene and widely distributed. It is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. It may play a fundamental role in situations where fine interplay between intracellular Ca(2+) and cAMP determines the cellular function. It also may be a physiologically relevant docking site for calcineurin. (NCI Thesaurus)
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