Health / Medical Topics

    ADRB2 wt Allele

    Human ADRB2 wild-type allele is located within 5q31-q32 and is approximately 2 kb in length. This allele, which encodes beta-2 adrenergic receptor protein, plays a role in the regulation of both calcium channel complex regulation and adenylyl cyclase activity. A variety of polymorphic forms of the gene are associated with nocturnal asthma, obesity and type 2 diabetes. These variants are frequently generated by point mutations and downregulation of the gene. (NCI Thesaurus)




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