| Health / Medical Topics |
Aerosolized Liposomal Rubitecan
An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin) and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter. (NCI Thesaurus)
YOU MAY ALSO LIKE
An aerosol formulation of aldesleukin, a recombinant form of interleukin-2 (IL-2), with potential immunostimulating activity. Upon IL-2 inhalation, this cytokine activates lymphokine-activated…
In medicine, to turn a liquid drug into a fine mist that can be inhaled.
A spray that is packaged under pressure and released upon activation of an appropriate valve system.
A homogenous solution comingled with a propellant and packaged under pressure. Upon activation of an appropriate valve system, the liquid is expelled…
An aerosol inhalation formulation containing a yeast-derived glycosylated recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF) with potential immunostimulating…
A container of medication intended to refill an aerosol dispenser.
