Health / Medical Topics

    Afatinib dimaleate

    Pronunciation

    Definition 1

    A drug used to treat non-small cell lung cancer that has spread to other parts of the body. It is used in patients with certain mutations (changes) in a cell protein called epidermal growth factor receptor (EGFR). It is also being studied in the treatment of other types of cancer. Afatinib dimaleate blocks certain EGFRs, which may help keep cancer cells from growing. It may also prevent the growth of new blood vessels that tumors need to grow. Afatinib dimaleate is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Also called Gilotrif. (NCI Dictionary)

    Definition 2

    The dimaleate salt form of afatinib, an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity. Upon administration, afatinib selectively and irreversibly binds to and inhibits the epidermal growth factor receptors 1 (ErbB1; EGFR), 2 (ErbB2; HER2), and 4 (ErbB4; HER4), and certain EGFR mutants, including those caused by EGFR exon 19 deletion mutations or exon 21 (L858R) mutations. This may result in the inhibition of tumor growth and angiogenesis in tumor cells overexpressing these RTKs. Additionally, afatinib inhibits the EGFR T790M gatekeeper mutation which is resistant to treatment with first-generation EGFR inhibitors. EGFR, HER2 and HER4 are RTKs that belong to the EGFR superfamily; they play major roles in both tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    An orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic…
    A synthetic peptide analogue of the naturally occurring alpha-melanocyte stimulating hormone (a-MSH) with potential photoprotective activity. Mimicking the action of a-MSH, afamelanotide…
    AF4/FMR2 family member 4 (1163 aa, ~127 kDa) is encoded by the human AFF4 gene. This protein plays a role in the…
    AF4/FMR2 family member 3 (1226 aa, ~133 kDa) is encoded by the human AFF3 gene. This protein is involved in the regulation…
    AF4/FMR2 family member 1 (1210 aa, ~131 kDa) is encoded by the human AFF1 gene. This protein may be involved in the…
    Expressed in a variety of cell types by human MLLT4 Gene, 1816-aa 206-kDa AF-6 Protein is a possible signal transduction protein controlled…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact