AFF4 wt Allele

Human AFF4 wild-type allele is located in the vicinity of 5q31 and is approximately 88 kb in length. This allele, which encodes AF4/FMR2 family member 4 protein, is involved in transcriptional regulation. A chromosomal aberration involving this gene and the MLL gene, insertion ins(5;11)(q31;q13q23), is associated with acute lymphoblastic leukemia. (NCI Thesaurus)

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AFF4 Gene

This gene plays a regulatory role in transcription and is involved in male germ cell differentiation.

AFF3 wt Allele

Human AFF3 wild-type allele is located within 2q11.2-q12 and is approximately 595 kb in length. This allele, which encodes AF4/FRM2 family member…

AFF3 Gene

This gene is involved in transcriptional activation and is purported to play roles in lymphoid development and oncogenesis.

AFF1 wt Allele

Human AFF1 wild-type allele is located in the vicinity of 4q21 and is approximately 206 kb in length. This allele, which encodes…

AFF1 Gene

This gene is involved in transcriptional regulation and translocations in the gene are associated with acute leukemia.

Afatinib dimaleate

A drug used to treat non-small cell lung cancer that has spread to other parts of the body. It is used in…