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ALTERED
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Changed in form or character without becoming something else
Example:
he looked...with clouded eyes and with an altered manner of breathing
Classified under:
Similar:
adjusted ((especially of garments) having the fit or style adjusted)
changed (made or become different in some respect)
edited; emended (improved or corrected by critical editing)
paraphrastic (altered by paraphrasing)
revised (improved or brought up to date)
Antonym:
unaltered (remaining in an original state)
Sense 2
Meaning:
Changed in order to improve or made more fit for a particular purpose
Example:
instructions altered to suit the children's different ages
Synonyms:
adapted; altered
Classified under:
Similar:
modified (changed in form or character)
Sense 3
Meaning:
Having testicles or ovaries removed
Synonyms:
altered; neutered
Classified under:
Adjectives
Similar:
castrated; unsexed (deprived of sexual capacity or sexual attributes)
II. (verb)
Sense 1
Past simple / past participle of the verb alter
Context examples:
Clinical signs include altered mental status, visual impairment and decreased muscle coordination.
(Alcohol-Induced Wernicke-Korsakoff's Syndrome, NCI Thesaurus)
After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.
(Beclomethasone, NCI Thesaurus)
A person who inherits an altered version of the BRCA2 gene has a higher risk of getting breast, ovarian, or prostate cancer.
(BRCA2 Gene, NCI Dictionary)
Normal genes, that when altered or inappropriately expressed, contribute to malignant transformation, tumor progression, or metastasis.
(Cancer Gene, NCI Thesaurus)
Expression of the allele is altered in non-Hodgkin lymphoma patients by a three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with the MYC gene and the immunoglobulin H locus.
(BCL7A wt Allele, NCI Thesaurus)
This allele, which encodes breast carcinoma amplified sequence 1 protein, plays a role in tumorigenesis and is associated with more aggressive tumor phenotypes when altered.
(BCAS1 wt Allele, NCI Thesaurus)
In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent.
(Attenuated Bacteria Vaccine, NCI Thesaurus)
Vaccination with these altered cells may elicit an anti-tumor immune response via CD8+ cytotoxic T lymphocytes (CTL).
(B7 Transfected Melanoma Cell Vaccine, NCI Thesaurus)
Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond.
(Base Excision Repair, NCI Thesaurus)
Treating wild-type mice with the antibodies after exposure to the Zaire ebolavirus appeared to have a protective effect, as did treating the altered mice after exposure to Sudan ebolavirus.
(Antibodies from Ebola survivor protect mice and ferrets against related viruses, NIH)
