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Alveolar soft part sarcoma
Pronunciation
Definition 1
A soft tissue tumor that is most common in older children and teenagers. It begins in the soft supporting tissue that connects and surrounds the organs and other tissues. Alveolar soft part sarcoma usually occurs in the legs, but can also occur in the arms, hands, head, or neck. It can cause the growth of new blood vessels that help the tumor grow and spread. Also called ASPS. (NCI Dictionary)
Definition 2
A rare malignant neoplasm characterized by the presence of large epithelioid cells with abundant cytoplasm forming nests and pseudoalveolar structures. The groups of the epithelioid cells are separated by thin-walled sinusoidal spaces. It occurs most often in adolescents and young adults. In adults the most common sites of involvement are the extremities, and in infants and children, the head and neck. It usually presents as a slowly growing mass and it frequently metastasizes to other anatomic sites. The most common sites of metastasis are the lungs, bone, and brain. (NCI Thesaurus)
Definition 3
A tumor predominantly affecting adolescents and young adults and composed of large, uniform epithelioid cells with abundant eosinophilic granular cytoplasm arranged in solid nests and/or solid structures. There is a recurrent cytogenetic aberration: der (17)t(X;17)(p11;q25). (NCI Thesaurus)
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