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Aminopterin
Pronunciation
Definition 1
An anticancer drug that belongs to the family of drugs called antimetabolites. (NCI Dictionary)
Definition 2
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI Thesaurus)
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