Amoxicillin-clavulanate potassium

Pronunciation

Definition 1

A drug used to treat bacterial infections. Adding the chemical clavulanate potassium to the antibiotic amoxicillin increases the amount of time the antibiotic stays active in the body. Amoxicillin-clavulanate potassium is a type of combination antibiotic. Also called Augmentin. (NCI Dictionary)

Definition 2

A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase enzyme inhibitor clavulanate potassium. Clavulanate potassium increases the serum half-life of amoxicillin by inhibiting beta-lactamase-mediated metabolism of amoxicillin. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell walls. (NCI Thesaurus)

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Amount Recovered Over Dosing Interval Normalized by Weight

The cumulative amount recovered from the specimen type specified in PPSPEC between doses (TAU) divided by weight.

Amount Recovered Over Dosing Interval Normalized by Surface Area

The cumulative amount recovered from the specimen type specified in PPSPEC between doses (TAU) divided by surface area.