Health / Medical Topics

    Androgen Receptor Antagonist ARN-509

    A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of…
    Androgen Metabolism consists of diverse biochemical reactions in the adrenal cortex that produce 19-carbon steroid hormones, which promote male sexual development or…
    A disorder of sexual development in persons with 46XY karyotype, characterized by an abnormality of the genes encoding androgen receptors. It results…
    Excessive secretion of androgens from the adrenal glands or gonads. Clinical manifestations may include virilization.
    Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking…
    An orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact