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Annamycin
Pronunciation
Definition 1
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anthracycline antibiotics. (NCI Dictionary)
Definition 2
A lipophilic, anthracycline antineoplastic antibiotic. Annamycin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis. This agent appears to not be a substrate for the p-glycoprotein associated multidrug-resistance (MDR) transporter; therefore, overcoming the resistance pattern seen with other anthracycline compounds. (NCI Thesaurus)
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