ANP32C Protein

Definition 1

Encoded by human ANP32C Gene, 234-amino acid 27 kD PP32R1 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R2. PP32 can inhibit several types of cancers, including prostate and breast cancers. PP32R1 and PP32R2 are tumorigenic. Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer. (from SWISS-PROT, OMIM, and NCI) (NCI Thesaurus)

Definition 2

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. This protein is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, ANP32C protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and ANP32C. (NCI Thesaurus/LocusLink)

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