| Health / Medical Topics |
Anti-PD-1 Fusion Protein AMP-224
An Fc-fusion protein containing a ligand of programmed death-1 (PD-1), with potential immunomodulating and antineoplastic activity. Anti-PD-1 fusion protein AMP-224 blocks the interaction between PD-1 and its ligands B7-DC (PD-L2 or programmed cell death-1 ligand 2) and B7-H1 (PD-L1 or CD274 molecule), thereby inhibiting the subsequent activation of PD-1. This may restore immune function and may result in the activation of T-cells and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein of Ig superfamily, negatively regulates T-cell activation and effector function when activated by its ligands, and plays an important role in tumor evasion from host immunity. (NCI Thesaurus)
YOU MAY ALSO LIKE
Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from…
An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Mimicking the natural OX4 ligand (OX40L), anti-OX40 monoclonal antibody selectively…
A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411 targets and binds to nucleolin, a nucleolar…
A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, anti-Notch1 monoclonal antibody OMP-52M51 binds to Notch-1…
A monoclonal antibody directed against the Notch receptor with potential antineoplastic activity. Anti-Notch receptor monoclonal antibody OMP-59R5 binds to Notch on the…
An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of…
