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APC
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A drug combination found in some over-the-counter headache remedies (aspirin and phenacetin and caffeine)
Classified under:
Nouns denoting man-made objects
Hypernyms ("APC" is a kind of...):
medicament; medication; medicinal drug; medicine ((medicine) something that treats or prevents or alleviates the symptoms of disease)
Sense 2
Meaning:
(military) an armored vehicle (usually equipped with caterpillar treads) that is used to transport infantry
Synonyms:
APC; armored personnel carrier; armoured personnel carrier
Classified under:
Nouns denoting man-made objects
Hypernyms ("APC" is a kind of...):
armored vehicle; armoured vehicle (a vehicle that is protected by armor plate)
Domain category:
armed forces; armed services; military; military machine; war machine (the military forces of a nation)
Context examples:
Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.
(Abatacept, NCI Thesaurus)
Encoded by human APCL Gene, 2303-amino acid 244 kD tumor suppressor APCL Protein is similar to APC and regulates formation of active Beta-Catenin/TCF complexes.
(Adenomatous Polyposis Coli Like Protein, NCI Thesaurus)
In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway.
(Allograft Rejection Pathway, NCI Thesaurus/KEGG)
In addition, H1-infected tumor cells strongly induce the release of the inducible heat shock protein 72 (Hsp72i), which chaperone tumor associated antigens in the H1-mediated tumor lysates and may activate antigen presenting cells (APCs), thereby leading to antitumor immune responses.
(Parvovirus H-1, NCI Thesaurus)
While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response.
(Pexastimogene-devacirepvec, NCI Thesaurus)
Upon intravenous administration, anti-CD40 monoclonal antibody Chi Lob 7/4 binds to CD40 on a variety of immune cell types, triggering the cellular proliferation and activation of antigen-presenting cells (APCs), activating B cells and T cells, and enhancing the immune response; in addition, this agent binds to the CD40 antigen present on the surfaces of some solid tumor cells, resulting in complement-dependent cytotoxicity (CDC) and antibody-dependent cytotoxicity (ADCC) eventually resulting in decreased tumor growth.
(Anti-CD40 Monoclonal Antibody Chi Lob 7/4, NCI Thesaurus)
Also called APC.
(Antigen-presenting cell, NCI Dictionary)
Investigating the link between gut bacteria and biological molecules called microRNAs (miRNAs) in the brain, researchers at the APC Microbiome Institute at University College Cork found that a significant number of miRNAs were changed in the brains of microbe-free mice.
(New Light on Link between Gut Bacteria, Anxiety, The Titi Tudorancea Bulletin)
Alefacept binds to the CD2 receptor expressed on the majority of T lymphocytes, blocking the binding of endogenous LFA-3, located on antigen-presenting cells (APCs), to the CD2 receptor; the activation and proliferation of T lymphocytes in response to LFA-3 binding is thus inhibited.
(Alefacept, NCI Thesaurus)
FBTA05 brings T cells, CD20-expressing tumor B-cells and APCs together into tricellular complexes, which may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B-cells.
(Anti-CD3/Anti-CD20 Trifunctional Bispecific Monoclonal Antibody FBTA05, NCI Thesaurus)
