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Aprepitant
Pronunciation
Definition 1
A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist. Also called Emend. (NCI Dictionary)
Definition 2
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. (NCI Thesaurus)
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Not quite exact or correct; almost exact or correct.
Protocol is approved by the review board.
Indicates the person or authoritative body who has given approval.
Stability data submitted to an approved application already filed with the FDA.
