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ASPARTIC ACID
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A crystalline amino acid found in proteins and occurring naturally in sugar beets and sugar cane
Classified under:
Hypernyms ("aspartic acid" is a kind of...):
amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)
Context examples:
A radiopharmaceutical agent comprised of a pegylated arginine-glycine-aspartic acid dimer (PRGD2) labeled with gallium Ga 68, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET) or single photon emission computed tomography (SPECT).
(Gallium Ga 68-labeled BNOTA-PRGD2, NCI Thesaurus)
Upon administration of erythrocyte-encapsulated L-asparaginase suspension, L-asparagine is hydrolyzed to L-aspartic acid and ammonia in plasma, thereby depleting tumor cells of asparagine.
(Erythrocyte-encapsulated L-asparaginase Suspension, NCI Thesaurus)
L-asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cells of asparagine; asparagine depletion blocks protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle and ultimately induces tumor cell death.
(Calaspargase Pegol, NCI Thesaurus)
Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations.
(Asparaginase, NCI Thesaurus)
Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in inflammation and apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades.
(Caspase Activation, NCI Thesaurus)
Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid.
(Aspartic Acid, NCI Thesaurus)
