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ATHEROSCLEROTIC
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Of or relating to atherosclerosis
Classified under:
Relational adjectives (pertainyms)
Pertainym:
atherosclerosis (a stage of arteriosclerosis involving fatty deposits (atheromas) inside the arterial walls, thus narrowing the arteries)
Derivation:
atherosclerosis (a stage of arteriosclerosis involving fatty deposits (atheromas) inside the arterial walls, thus narrowing the arteries)
Context examples:
The responsible thrombus appears to be generated by interactions between the atherosclerotic plaque, the coronary endothelium, circulating platelets, and dynamic vasomotor tone of the vessel wall, all of which overwhelm natural protective mechanisms.
(Acute Myocardial Infarction Pathway, NCI Thesaurus/BIOCARTA)
Calorie restriction was found to improve risk factors for the development of atherosclerotic cardiovascular disease and related deaths well below clinical risk thresholds.
(Moderate calorie restriction in young and middle-aged adults significantly reduces heart and metabolic risk factors independent of weight loss, National Institutes of Health)
The researchers also showed that sleep-deficient, atherosclerotic mice that received hypocretin supplementation tended to produce fewer inflammatory cells and develop smaller atherosclerotic lesions when compared to mice that did not get the supplementation.
(Study helps solve mystery of how sleep protects against heart disease, National Institutes of Health)
Overabundance or increased activity of the plasminogen activator inhibitors or reduced presence or function of tPA or uPA can result in atherosclerotic disease and venous thrombosis due to an increase in fibrin deposition or formation of a thrombus.
(Fibrinolysis Pathway, NCI Thesaurus/BIOCARTA)
Approximately 90% of MI results from formation of an acute thrombus that obstructs an atherosclerotic coronary artery.
(Acute Myocardial Infarction Pathway, NCI Thesaurus/BIOCARTA)
Eflucimibe is an inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme which catalyzes the esterification of cholesterol into cholesteryl esters and is believed to be involved in intestinal cholesterol absorption, lipoprotein assembly in the liver, steroid hormone production in the adrenal cortex, and foam cell formation in atherosclerotic lesions.
(Eflucimibe, NCI Thesaurus)
