Auranofin

An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis. (NCI Thesaurus)

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AUMC Over Dosing Interval Normalized by Weight

The area under the first moment curve (AUMC) for the defined interval between doses (TAU) divided by the weight.

AUMC Over Dosing Interval Normalized by Surface Area

The area under the first moment curve (AUMC) for the defined interval between doses (TAU) divided by the surface area.

AUMC Over Dosing Interval Normalized by Dose

The area under the first moment curve (AUMC) for the defined interval between doses (TAU) divided by the dose.

AUMC Over Dosing Interval Normalized by Body Mass Index

The area under the first moment curve (AUMC) for the defined interval between doses (TAU) divided by the body mass index. …