Aurora A Kinase Inhibitor MK5108

An orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A, with potential antimitotic and antineoplastic activity. Aurora A kinase inhibitor MK5108 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and eventually inhibition of cell division, proliferation and an induction of apoptosis in cells overexpressing Aurora A kinase. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aurora kinases are overexpressed in a wide variety of cancers. (NCI Thesaurus)

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Human AURKC wild-type allele is located in the vicinity of 19q13.43 and is approximately 5 kb in length. This allele, which encodes…

AURKC Gene

This gene is involved in protein phosphorylation and mitosis.

AURKB wt Allele

Human AURKB wild-type allele is located in the vicinity of 17p13.1 and is approximately 6 kb in length. This allele, which encodes…

AURKB Gene

This gene is involved in mitosis and meiosis.

AURKA wt Allele

Human AURKA wild-type allele is located within 20q13.2-13.3 and is approximately 23 kb in length. This allele, which encodes serine/threonine-protein kinase 6…

AURKA Gene

This gene is involved in cell cycle regulation and cell survival.