Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076

An orally bioavailable synthetic small molecule with potential antiangiogenic and antineoplastic activities. Aurora A kinase/tyrosine kinase inhibitor ENMD-2076 selectively binds to and inhibits non-specified tyrosine kinases and Aurora kinases (AKs). The inhibition of AKs may result in the inhibition of cell division and proliferation and may induce apoptosis in tumor cells that overexpress AKs; antiangiogenic activity is related to the inhibition of angiogenic tyrosine kinases. AKs are serine-threonine kinases that play an essential role in mitotic checkpoint control during mitosis and are important regulators of cell division and proliferation. (NCI Thesaurus)

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This gene is involved in protein phosphorylation and mitosis.

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Human AURKB wild-type allele is located in the vicinity of 17p13.1 and is approximately 6 kb in length. This allele, which encodes…

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This gene is involved in mitosis and meiosis.

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