autologous expanded mesenchymal stem cells OTI-010

Pronunciation

Definition 1

A product that is made of special stem cells taken from a patient’s bone marrow and grown in the laboratory. After a patient’s bone marrow is destroyed by treatment with whole body irradiation or chemotherapy, these cells are injected back into the patient to help rebuild bone marrow. Autologous expanded mesenchymal stem cells OTI-010 has been studied in the prevention of graft-versus-host disease during stem cell transplant in patients receiving treatment for cancer. Autologous expanded mesenchymal stem cells OTI-010 is used in cellular therapy. Also called Stromagen. (NCI Dictionary)

Definition 2

Multipotent self-renewing adherent non-hematopoietic stromal cells harvested from a patient's bone marrow and grown in vitro. When injected back into the patient, autologous expanded mesenchymal stem cells OTI-010 may differentiate into various mesenchyme-derived cell types and, in some instances, may augment bone marrow engraftment after whole-body irradiation. (NCI Thesaurus)

YOU MAY ALSO LIKE

Autologous Epstein-Barr Virus-Transformed B-Lymphoblastoid Cell Vaccine

A cell-based vaccine composed of autologous lymphoblastoid B cells activated against Epstein-Barr virus (EBV) in vitro with potential immunoprotective activity. Upon prophylactic…

Autologous Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes

A preparation of lymphocytes harvested from a patient with an Epstein-Barr virus (EBV)-positive tumor. Ex vivo, the lymphocytes are activated against…

Autologous EBV-Transformed B Lymphoblastoid-Tumor Fusion Cell Vaccine

A cell-based vaccine composed of autologous tumor cells fused with Epstein-Barr virus-transformed B-lymphoblastoid cells. Upon administration, this vaccine may stimulate a cytotoxic…

Autologous EBV-CTL CD19CAR zeta

Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the…

Autologous Dinitrophenyl-Modified Ovarian Cancer Vaccine

A cancer vaccine consisting of autologous ovarian cancer cell peptide antigens conjugated to the hapten 2,4-dinitrophenol (DNP) with potential immunostimulating and antineoplastic…

Autologous Dinitrophenyl Vaccine

A vaccine consisting of autologous cancer cells modified with the hapten, Dinitrophenyl. The treatment program consists of multiple intradermal injections of irradiated…