Health / Medical Topics

    Aziridinylbenzoquinone RH1

    A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    Azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T…
    The potassium salt of a narrow-spectrum, semisynthetic penicillin derivative with antibacterial activity. Azidocillin binds to and inactivates penicillin-binding proteins (PBPs) located on…
    A narrow-spectrum, semisynthetic penicillin derivative with antibacterial activity. Azidocillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of…
    Human AZGP1 wild-type allele is located in the vicinity of 7q22.1 and is approximately 9 kb in length. This allele, which encodes…
    This gene plays a role in lipid catabolism.
    An azirine-based thiotepa derivative with alkylating activity. Azetepa is able to alkylate and crosslink DNA, causing DNA damages and eventually an inhibition…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact