| Health / Medical Topics |
B-Cell Lymphoma 9 Protein
Expressed in thymus, prostate, testis, ovary, small intestine, spleen, colon, and blood, 85-kb human BCL9 Gene at 1q21 encodes 1426-aa 150-kD nuclear B-Cell Lymphoma 9 Protein, containing an HD1 domain that interacts with the conserved PHD finger of PYGO1 and PYGO2. BCL9 (Lgs homolog, Drosophila) also binds to beta-Catenin, involved in WNT signal transduction pathway control of many fundamental developmental processes. BCL9 recruitment of PYGO to beta-Catenin may permit association with DNA-binding TCF to transcriptionally activate WNT target genes. BCL9 translocation that leaves the coding region intact is associated with B-cell acute lymphoblastic leukemia. (NCI Thesaurus)
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