| Health / Medical Topics |
B-Cell Survival Pathway
Physical interactions between integrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, survivin, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. (NCI Thesaurus/BIOCARTA)
YOU MAY ALSO LIKE
A membrane bound protein complex comprised of an immunoglobulin molecule associated with a heterodimer, called CD79, containing one CD79A protein and one…
B-cell receptor CD22 (847 aa, 95 kD) is a cell adhesion process protein that is encoded by the human CD22 gene and…
A process that involves the binding of an antigen to the transmembrane B cell receptor, an IgD molecule. These interactions are involved…
A malignant B-cell lymphoproliferative process affecting the blood, bone marrow, and spleen. The B-prolymphocytes are medium-sized, round lymphoid cells with prominent…
The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma,…
A type of cancer that forms in B cells (a type of immune system cell). B-cell lymphomas usually occur in adults and…
