Health / Medical Topics

    B-Raf/VEGFR-2 Inhibitor RAF265

    An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A developmental form in the B-lymphocyte series, intermediate between the B-lymphoblast and the mature B-cell.
    Rare, Thymectomized line of mice only, B220+, CD5+.
    An incomplete or c-shaped microtubule that is part of a microtubule doublet in cilia.
    Malignant transformation and proliferation of B lymphocytes.
    B-lymphocyte antigen CD20 (297 aa, ~33 kDa) is encoded by the human MS4A1 gene. This protein plays a role in both the…
    Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact