Health / Medical Topics

    Baclofen/amitriptyline/ketamine gel

    Pronunciation

    Definition 1

    A substance being studied in the treatment of peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) caused by chemotherapy. It contains three drugs, baclofen, amitriptyline, and ketamine, that relax muscles by blocking nerve receptors. The gel is applied to the skin of affected areas. It is a type of analgesic. Also called BAK gel. (NCI Dictionary)

    Definition 2

    A topical preparation of baclofen, amitriptyline, and ketamine compounded in a penetration-enhancing polaxamer-lecithin organogel (PLO) with potential antineuralgic activity. The gamma-aminobutyric acid (GABA) analogue baclofen appears to activate the inhibitory GABA(B) receptor, a G protein-coupled receptor, which may result in hyperpolarization of the neuronal cell membrane and inhibition of neurotransmitter release. Amitriptyline likely produces antineuralgic effects via modulation of multiple subtypes of glutamate (Glu) receptors, independent of its antidepressant actions. Ketamine displays complex pharmacologic actions including biogenic amine uptake inhibition, interaction with opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Stimulation of GABA(B) receptor activity, modulation of Glu receptor activity, and inhibition of NMDA receptor activity may be of benefit in managing neuropathic pain. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A drug that is used to treat certain types of muscle spasms and is being studied in the treatment of liver…
    A circuit board with connectors into which other cards are plugged.
    The essential oil of Backhousia citriodora. One form of lemonmyrtle oil is used as a flavoring or for its aromatic properties. The…
    A method to adjust detector intensities to correct for background variation in intensities.
    Existing conditions, especially those that would be confused with the phenomenon to be observed or measured.
    The bones, muscles, tendons, and other tissues that reach from the base of the skull to the tailbone. The backbone encloses the…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact