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Bacterial Artificial Chromosome
Definition 1
Based upon the natural F plasmid of E. coli. Inserts up to 300 Kb can be cloned and stably maintained as circular molecules. (NCI Thesaurus)
Definition 2
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes. (NLM, Medical Subject Headings)
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