| Health / Medical Topics |
Basal Transcription Factor Gene
Human Basal Transcription Factor Genes encode Basal Transcription Factors, a diverse group of general factors required for transcription of all eukaryotic PolII genes. Initiation of transcription from eukaryotic protein-coding genes is a complex process requiring RNA polymerase II (PolII) and a cadre of transcription factors. The general transcription factors and PolII form a multiprotein complex near the transcription start site by interacting with core promoter elements. The most common core element is the TATA box, typically 25-30 bp upstream of the start site. (NCI Thesaurus)
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Basal Transcription Factors are prokaryotic and eukaryotic proteins that cooperate with DNA-dependent RNA polymerases to initiate, inhibit or terminate transcription.
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