Bcl-2-Interacting Killer

Bcl-2-binding component 3 (193 aa, ~21 kDa) is encoded by the human BBC3 gene. This protein plays a role in the regulation…

An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. GDC-0199 mimics BH3-only proteins, the native…

Proteins that are related to bcl-2 are characterized by the presence of one or more highly conserved stretches of homology with bcl-2,…

Bcl-2 homologous antagonist/killer (211 aa, ~23 kDa) is encoded by the human BAK1 gene. This protein is involved in both protein-protein interactions…

The BCL-2 Gene Family encodes proteins that contain Bcl-2 homology (BH) domains (1, 2, 3, or 4), involved in interactions among apoptotic…

A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that…