BH1 Domain

Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BH1 contains predominantly hydrophobic residues. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI Thesaurus)

YOU MAY ALSO LIKE

BGN wt Allele

Human BGN wild-type allele is located in the vicinity of Xq28 and is approximately 15 kb in length. This allele, which encodes…

BGN Gene

This gene plays a role in extracellular matrix structure.

BGLAP wt Allele

Human BGLAP wild-type allele is located within 1q25-q31 and is approximately 1 kb in length. This allele, which encodes osteocalcin protein, plays…

BGLAP Gene

This gene is involved in bone structure and the regulation of bone formation.

BG04

Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4,…

BG03

Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4,…