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BIRC3/MALT1 Fusion Gene
A fusion gene that results from a chromosomal translocation t(11;18)(q21;q21) which fuses the 5' portion of the BIRC3 gene to the 3' portion of the MALT1 gene. This rearrangement is associated with extra-nodal presentation of marginal zone B-cell lymphoma. (NCI Thesaurus)
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This anti-apoptotic gene regulates apoptotic activity. BIRC3 gene promotes tumor cell survival.
Human BIRC2 wild-type allele is located in the vicinity of 11q22 and is approximately 30 kb in length. This allele, which encodes…
This gene is a potent inhibitor of apoptosis and plays an important role in apoptotic signal transduction.
A rod shaped cytoplasmic organelle found in Langerhans cells of the epidermis.
Containing perfectly conserved histidine and cysteines residues. the BIR domain is about 70 residues long arranged in tandem repeats separated by a…
